From an early age, Chris was influenced by his father’s career. Brian Duffy (only ever known as Duffy), with David Bailey and Terence Donovan, was one of the trio of famed photographers who changed the face of photography in the Swinging Sixties. 

Chris began his photography career as a trainee processor at Colour Photo Labs in London in 1972, quickly advancing to assisting and becoming his father's studio manager. He travelled extensively with his father for seven years on various photographic assignments and award-winning campaigns, opening his own studio in 1979. He shot Bowie, Sade, Adam Ant, and many pop album covers. ‘Love Glove’ for Visage with Steve Strange was just one of many.

His fashion and assignments for Vogue, French Elle, Cosmopolitan, etc., continued. In 1986, Chris, brother Carey, and his father opened a full-facility film production company called 3DZ (Duffy, Duffy & Duffy). Amongst others, they shot TV Commercials for Diet Coke, British Steel, and Elle Magazine. As a Director of Photography, Chris was known for his work on pop promos with Underworld, Nick Hayward, Kevin Rowland of Dexys Midnight Runners, Sigue Sigue Sputnik, etc. Corporate films and TV commercials. 

In I989, Chris relocated to Los Angeles, returning to London in 1997 on the wave of ‘Cool Britannia’. He resumed his photographic career shooting for GQ and the new ‘Lads Mags’ and shot portraits of Robert Plant, Jimmy Page, Midge Ure, and many others. Picking up on the digital revolution, Chris founded SIX, a multi-media production company developing websites, online streaming, corporate films, and interactive multi-language DVDs for clients.

In 2005, Chris began developing an archive of Duffy's work, which launched in 2009. Today, Duffy’s work is exhibited worldwide and held in the collections of major exhibitions. Chris manages the archive while continuing to pursue his photography and speak on the subject. Chris continues to shoot outside of commercial restraints, promotes Duffy's work, and is a well-regarded speaker.